To evaluate the aforementioned methods for extracting properties, we randomly chose 1000 listings for each property and manually annotated the properties as ground truth. We evaluated our method on our annotated data set, which yields an accuracy of over 90% for each property extraction, as shown in Table 5. In this way, we collected 7100 promotion posts and 6408 review posts from forum posts in total. Finally, in the model refining stage, the model is trained for other 2 iterations using the same objective function. We manually investigated the results by randomly sampling 10% of data records during each iteration and adding false positive samples into the unlabeled set.
Pakistan Pancreatic And Bile Duct Cancer Market data and reports
When interpreted by professionals, our initial results demonstrate useful findings and may be used downstream by law enforcement and public policy makers for impactful structural interventions to the opioid crisis. Although a large body of current research is focused on pathways for treatment of opioid use disorder and analyzing deaths per treatment capacity of substance use providers, these research areas are limited to the demand side of the opioid epidemic [40,41]. We believe that the findings and pattern analyses presented here, which place concentration on the supply side, might suggest drug hub market a new direction to focus and will serve as a useful complement to current research conducted within the domain of addiction medicine. This section elaborates on the methodology used to identify opioid trading information in the anonymous market and forums. Specifically, we collected approximately 248,359 unique listings and 1,138,961 unique forum traces (ie, threads of posts) from 10 anonymous online marketplaces and 6 forums. We then identified 311 opioid keywords and jargons to recognize 28,106 listings and 13,508 forum traces related to underground opioid trading activities.
How to Get Your Private Mirrors
The opioid buyer (client) will also access the anonymous online market and create an account in each anonymous marketplace before they can find the listings of opioids (step 4). After perusing the items available on the anonymous online market (step 5), the buyer will add opioids to their shopping cart (step 6). When the buyer wants to check out and make a purchase using cryptocurrency (eg, Bitcoin), if the trader accepts payment through an anonymous online marketplace as an escrow, the buyer will place the listed amount of cryptocurrency in escrow (step 7).
🚀 Welcome to DrugHub Market 🌐
In the above objective function, C+ is always larger than C−, which means that the penalty of misclassifying a positive instance is larger than that of a negative instance. In general, the correlation between the penalty factors and the number of samples is set as , where P and C are the sizes of Dp and Dc, respectively. Infrastructure development, manufacturing expansion, and technology adoption offer strong opportunities.
Platform
The review detection model yielded a mean precision of 81.5% and an average recall of 80.1%, whereas for the promotion detection model, it yielded a mean precision of 88.1% and an average recall of 85.1% (Table 4). At Market Research Intellect, our mission is to bridge the gap between data and decision-making. We partner with organizations of all sizes—from startups to Fortune 500 companies—to help them optimize strategies, strengthen competitiveness, and drive sustainable growth. Our commitment to quality research and client success has established us as a trusted name in global market intelligence. The Pancreatic And Bile Duct Cancer Drug Market refers to the global industry involved in the development, production, and deployment of Pancreatic And Bile Duct Cancer Drug solutions across various end-use sectors.
Market Analysis of Pancreatic and Bile Duct Cancer Drugs: Trends, Opportunities, and Regional Insights
Industry analysts compare market participants and measure performance through in-depth interviews, analyses, and extensive secondary research to identify best practices in the industry. Revolutionizes pre-clinical and clinical drug development through its cutting-edge organoid technology, enhancing its accuracy and efficiency. Established through the merger of G42 Healthcare and Mubadala Health, M42 is fast-becoming a major player in global healthcare. The company already employs more than 20,000 people, and operates over 480 facilities across 26 countries, integrating genomics, biobanks, digital health data and AI technologies to deliver predictive, personalized healthcare.
Experienced Vendors
Pharmacy benefits managers (PBMs) are working with employers to cover these medications through prior authorization models. Prescribers are treating these serious conditions, prescribing drugs with complex distribution channels and prior authorizations. “It may be that a person’s entire experience of using drugs has actually started through the darknet, and may indeed be confined to the darknet,” she explained.
🔒 Secure Escrow System
Most recently, Swiss pharma behemoth Novartis unveiled plans to build a new radioligand therapy manufacturing facility in Winter Park, Florida, as part of a $23 billion U.S. investment pledge announced in April 2025. Another critical vulnerability lay in the platform’s Jabber server configuration. Public documentation revealed the use of port 5222, a choice that, while functional, is fraught with risks. This port, coupled with the use of both Tor and clearnet mirrors, significantly increased the attack surface for adversaries. The possibility of intercepting user data became more than a theoretical risk—it was a plausible scenario that could compromise both buyers and vendors alike.
Early-Life Gut Bacteria Linked to Lower Risk of Allergies and Asthma in Children
The hub can complete benefits investigation, review formulary requirements, explore co-pay assistance offerings, and identify prior authorizations or step therapy requirements. The hub vendor specifically services this patient set and works diligently to resolve problems, thereby boosting compliance and preventing abandonment. When prescribing a specialty medication that has available hub services, a prescriber can send referrals directly to the hub. This breaks down barriers to the patient receiving medication therapy. As previously alluded, hubs were created in the 1990s mainly to assist with benefit and reimbursement services for patients and providers. Among other services, this offering continues today and is a cornerstone service of many hubs.
Health Sciences North/ Horizon Santé Nord (Greater Sudbury)
One unsurprising consequence is that it gives consumers unprecedented ease of access to illicit—and oftentimes mysterious—substances. Each year, somewhere around a quarter to a third of GDS respondents say that they’ve consumed a wider range of drugs since using the dark web. The breadth of the darknet’s product offering, combined with the relatively low barrier to entry, creates gateways to novel drug-using behaviours, where people try new substances just because they’ve suddenly been made available to them. Drugshub.su serves as a dynamic link generator, providing short-term access in the event the principal links are not accessible. Learn how we’re keeping our communities safer and improving access to mental health through the transition of nine supervised drug injection sites into HART Hubs.
🚨 DrugHub is the leading darknet marketplace for verifiedvendors, over 100,000+ listings, over 500,000 active users, and more than 4,000 trusted vendors. Launched in August 2023 bythe legendary team behind White House Market, DrugHub has quickly become the topdarknet market globally. Law enforcement agencies around the world seized an online marketplace and arrested nearly 300 people allegedly involved in buying and selling drugs, European Union law enforcement agency Europol said Tuesday. DrugHub’s origins trace back to the remnants of White House Market and its eventual merger with Supermarket. The platform’s creators, likely seasoned veterans of the darknet ecosystem, should have known better than to leave such glaring vulnerabilities.
Finally, we used natural language processing techniques to extract opioid trading information to characterize underground opioid commodities, suppliers, and transactions. In total, we collected 248,359 listings from 10 anonymous online marketplaces and 1,138,961 traces (ie, threads of posts) from 6 underground forums. As observed in our data set, the top 3 marketplaces with the most opioid listings are Agora, Evolution, and Apollon. Our research collected product listings and forum posts from 10 anonymous online market places and 6 forums. Our study determined the underground marketplace and forum list based on darknet site search engines and previous research works [20]. More specifically, we used darknet site search engines (such as Recon, Darknet live, Dark Eye, dark.fail, and DNStats [21,22]) to search underground marketplaces and forums and then manually validated their activeness.
- Nevertheless, this does pose challenges and it is imperative to keep patient information away from the operations of the business.
- Most recently, Swiss pharma behemoth Novartis unveiled plans to build a new radioligand therapy manufacturing facility in Winter Park, Florida, as part of a $23 billion U.S. investment pledge announced in April 2025.
- Customers pay a standard 5% commission that can be adjusted based on account activity and volume.
- After that, an opioid buyer often leaves review comments under the product listing or discusses the purchasing experience in the forum (step 12).
- If canary is not updated or signature fails verification, assume compromise.
Select the active mirror above and copy the .onion URL to your clipboard. This onion is protected by custom sophisticated CAPTCHA systems and POWenabled to give you the best experience using DrugHub market. This said… at this point in time I would not be surprised if DrugHub has been had it’s servers imaged by Law Enforcement and investigations at this point are probably underway. Always encrypt sensitive communications using the appropriate staff key.
Pinecrest Queensway Community Health Centre (Ottawa)
The life sciences industry continues to pour manufacturing investments into the state. GSK announced plans in September to build an additional new biologics flex factory at Upper Merion focused on medicines for respiratory disease and cancer, with construction planned to start this year. It’s part of a bigger $1.2 billion investment in advanced manufacturing facilities, AI and advanced digital technologies that will also include new capabilities. With its business-friendly environment and Texas Medical Center’s biomanufacturing project, TMC BioPort, the state proved an attractive investment location for other companies in 2025, too. Novartis plans to build two new radioligand therapy manufacturing facilities in Florida and Texas, and in October, the U.K.’s AstraZeneca opened an expanded manufacturing facility in Coppell to double the production of its high blood potassium treatment, Lokelma.
Ford government addiction hubs will open before supervised consumption sites close
Note that we should not overestimate the number of suppliers and buyers given the number of IDs found in this research, but we regarded it as the upper-bounded number of the opioid suppliers and buyers. This is because the same user could have different IDs, and the same ID in different marketplaces can point to different users. Owing to the anonymity of the underground marketplaces and forums, there exists no ground truth to link users with their IDs. The Drug Hub editorial team is made up of people who use(d) drugs, students, researchers, and healthcare professionals who work with marginalized and criminalized communities.
- Infrastructure development, manufacturing expansion, and technology adoption offer strong opportunities.
- These shadow operators have been romanticized in Hollywood films that present them in the archetype of the rugged frontiersman and cowboy who does what is necessary to defeat the nation’s evil, and invariably, dark-skinned foes.
- Only quality sellers who meet our standards are approved to ensure buyer safety.
- Vendors receive fair treatment with competitive fee structures and no hidden charges.
- To identify forum posts related to opioid commodity promotion and review, our methodology was designed to filter forum posts with opioid keywords and then use a classifier to the posts with the topics of interest.
- The Drug Hub editorial team is made up of people who use(d) drugs, students, researchers, and healthcare professionals who work with marginalized and criminalized communities.
- The use of outdated software was not just a cosmetic flaw; it signaled a broader negligence in keeping up with technological advancements.
The government also unveiled plans to stop other supervised drug injection sites from opening in Ontario, going against its own expert advice but citing rising crime and complaints from neighbours. Nitazenes are a new synthetic opioid drug that has emerged in the UK drug supply. The hub may be there for patient education and support, co-pay assistance, pharmacy triage, or a series of other reasons. Therefore, as a partner to the patient, the hub is tasked to improve patient care and outcomes, which is something every pharmacist can get behind. While performing many duties, the hub functions to simplify the path from manufacturer to patient.
Hub services act to simplify the complexity and perform as an intermediary between involved parties. The seized drugs include over 569 pounds of amphetamines, 95 pounds of cocaine, 95 pounds of MDMA and over 22 pounds of LSD and ecstasy pills, the agency said. Among them is Amgen, which in April announced a $900 million expansion of its Ohio manufacturing facility as part of a $1.4 billion investment plan it said has created 750 jobs. In addition, J&J kicked off 2026 by announcing plans to build a next-generation cell therapy manufacturing site in Pennsylvania.
Its assets include Cleveland Clinic Abu Dhabi and Moorfields Eye Hospital Abu Dhabi, as well as initiatives like the Emirati Genome Program and Abu Dhabi BioBank. We are a pan-Canadian collective of harm reductionists, drug policy activists, and people who use(d) drugs. Jessica Lyons, a registered nurse and CUPE union leader who works at a consumption site in Toronto, said they reversed 517 overdoses last year. They supervised more than 1,000 visits, she said, and 116 people received primary care through its wraparound services. That gap also worries advocates who are imploring Premier Ford to change his mind about closing down supervised consumption sites, warning drug problems will become more visible and more fatal — even with new funding — if he does not. However, the pharmacist is concerned the most with one stakeholder in particular—the patient.
Ultimately, Hub Services are indispensable in bridging the gap between patients and the life-saving therapies they require. As observed in our data set, the opioid suppliers in the marketplaces Evolution, Pandora, and Silk Road accepted escrow as a method of payment. In fact, the shutdown of the marketplace Evolution was discovered to be an exit scam, with the site’s operators shutting down abruptly to steal the approximately US $12 million in bitcoins that it was holding as an escrow [39]. Inspired by the work [36] investigating the supplier migration phenomenon between underground marketplaces, we also evaluated the migrant suppliers who, for the first time, began to trade in a new market, m’, after the closure of marketplace m.
Novartis broke ground on a 700,000-square-foot flagship manufacturing hub in December. Slated to open in by 2028, the project includes a new facility in Morrisville and a new site in Durham, as well as expansion of an existing Novartis facility in Durham. Pledged projects have landed in a handful of hotspots while giving rise to potential new hubs across the U.S.
The drugmaker followed that up with a $2 billion deal in September for manufacturing space at Fujifilm Biotechnologies’ Holly Springs location. It also recently announced plans to build a second multibillion-dollar facility in Wilson. That dollar amount continues to tick up, with drugmakers announcing new projects at a steady clip.
We are the premier platform for secure, private, Monero(XMR)-only transactions, with industry-leading security and uptime. It is becoming more common for medications to have strict storage and shipment requirements, especially for costly specialty medications. Thus, dispensing hubs have working knowledge of the supply chain requirements for medications and the hub can also triage prescriptions to SPP partners that are participating in limited distribution networks. The hub provides access to the maximum number of covered lives, while maintaining tight control over medication distribution. To identify forum posts related to opioid commodity promotion and review, our methodology was designed to filter forum posts with opioid keywords and then use a classifier to the posts with the topics of interest. The classifier was built upon transfer learning and a crafted objective function that heavily weighs the penalty of misclassifying a positive instance.
Xylazine has been found in drugs across the UK and can lead to serious wounds amongst other risks. You can save a life with naloxone available for free from your local drug service. Therefore, because of the advantage that the pharmaceutical manufacturer receives for the distribution of medication, they will periodically elect to operate a hub in-house. Nevertheless, this does pose challenges and it is imperative to keep patient information away from the operations of the business. A hub that operates to maintain REMS reporting requirements can provide valuable information for these reevaluations. This can occur when benefits investigation is ongoing or when a servicing pharmacy is no longer in network.